Abstract Search

ba0001ni6 | (1) | ECTS2013

Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-κB activation in vitro

Obaid Rami , Wani Sachin , Ralston Stuart , Albagha Omar

see PP230....

0 shares

ba0001pp230 | Cell biology: osteoclasts and bone resorption | ECTS2013

Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-κB activation in vitro

Obaid Rami , Wani Sachin , Ralston Stuart , Albagha Omar

OPTN encodes a cytoplasmic protein optineurin which has been shown to play a role in autophagy. Recent GWAS studies have shown that variants within OPTN are associated with the risk of Pagets disease of bone, a disease characterized by focal areas of increased bone turnover due to increased osteoclast activity, suggesting a possible role of OPTN in the regulation of bone metabolism.The aim of this study was to investigate the role of optineurin in ...

0 shares

ba0001op37 | Pre-Clinical | ECTS2013

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in Optn^D477N/D477N mice

Wani Sachin , Obaid Rami , Jones Ruth , Cohen Philip , Ralston Stuart , Albagha Omar

see PP229....

0 shares

ba0001pp229 | Cell biology: osteoclasts and bone resorption | ECTS2013

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in Optn^D477N/D477N mice

Wani Sachin , Obaid Rami , Jones Ruth , Cohen Philip , Ralston Stuart , Albagha Omar

Recent GWAS have identified variants in the OPTN gene that predispose to Pagets disease of Bone (PDB), a disease characterised by focal areas of increased bone turnover and enhanced osteoclast activity, suggesting a role for this gene in bone metabolism. The aim of this study was to investigate the role of OPTN in bone metabolism using a mouse model (OptnD477N/D477N) which harbours a D477N point mutation in the polyubiquitin binding ...

0 shares

Bone Abstracts

Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-κB activation in vitro

Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-κB activation in vitro

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in Optn^D477N/D477N mice

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in Optn^D477N/D477N mice

BiosciAbstracts

Bone Abstracts

Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-κB activation in vitro

Depletion of the autophagy adaptor OPTN leads to increased osteoclast formation, fusion and survival as well as increased NF-κB activation in vitro

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in OptnD477N/D477N mice

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in OptnD477N/D477N mice

BiosciAbstracts

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in Optn^D477N/D477N mice

The D477N mutation in OPTN leads to increased bone turnover and enhanced osteoclast formation in Optn^D477N/D477N mice